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Commonly reported symptoms include: Nausea Gastrointestinal discomfort Transient appetite changes Fatigue or headache These effects are generally dose-dependent and tend to diminish over time as the body adjusts

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oxidative stress, calcium overload, and glutamate toxicity may also lead to energy deficiencies, forming a vicious cycle with -synuclein accumulation

For patients on bisphosphonates, we should be alert to new hip or thigh pain