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GLP-1 receptor agonists, like semaglutide and tirzepatide, can slow down how quickly your stomach empties

[DOI] [PMC free article] [PubMed] [Google Scholar] 759.Navarro M., Rodriquez de Fonseca F., Alvarez E., Chowen J.A., Zueco J.A., Gomez R

However, native GLP-1 undergoes rapid enzymatic degradation by dipeptidyl peptidase-4 (DPP-4), resulting in a short half-life (~ 2 min), thus limiting its clinical applicability [65, 66]

Comprehensively, our results indicate that GLP-1R agonist pharmacotherapy produces distinct cellular responses in VTA GABA and dopamine neurons of cocaine-experienced rats