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The standard tirzepatide dosage chart for weight loss starts at 2.5 mg once weekly for 4 weeks, then increases by 2.5 mg increments every 4 weeks as tolerated: 2.5 mg 5 mg 7.5 mg 10 mg 12.5 mg 15 mg (maximum)

Durability of tirzepatide for long-term weight loss and glycemic control are still under study and not yet proven

When phase 3 data pushed retatrutide to 28.7% at the highest dose, the gap widened further

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Both groups eventually reached the same maintenance doses, but the path to get there was dramatically different in terms of comfort and adherence