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2019, doi: 10.3389/fendo.2019.00376

Patients who are not tolerating the maximal dose of a once-weekly GLP-1 receptor agonist, or those who are switching once-weekly GLP-1 receptor agonists due to GI adverse effects, should delay the initiation of the new GLP-1 receptor agonist therapy until symptoms have resolved

To test this possibility, we performed cgMD simulations of GLP-1R in active versus inactive conformations in a model mammalian plasma membrane using the latest Martini 3 forcefield and cholesterol parameters, identifying specific receptor sites with high cholesterol occupancies and residence times

Abnormal regulation of glutamatergic receptors appears to participate in diabetes-induced impairment of synaptic plasticity

Our findings align with emerging preclinical research and contribute to a growing body of literature related to GLP-1 RA use in oncology settings, said study lead author Kristina L