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Mol Metab 49, 101181 (2021)

doi: 10.2337/diabetes.52.1.102 125 FarillaLHuiHBertolottoCKangEBulottaADi MarioUet al

Accordingly, moderate lean tissue decline observed during GLP-1RA-induced weight loss could be interpreted as a physiological component of body composition change rather than evidence of pathological sarcopenia, unless accompanied by functional deterioration

Spielmans GI, Berman MI, Linardatos E, Rosenlicht NZ, Perry A, Tsai AC

I would say number one, for osteoarthritis, high-quality, randomized evidence shows that substantial weight loss with semaglutide can significantly reduce knee pain and improve function

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