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Methods: The PubMed/Medline, Cochrane Clinical Trial, and EMBASE databases were interrogated with a pre-defined search strategy and eligibility criteria to examine the evidence regarding GLP-1RAs use in IBD and non-IBD immune-mediated inflammatory disease (IMID) patients

The mean differences in A1c and body weight between IDegLira and basalbolus therapy and IDeglira and basal glargine were 0.3% and 6.89 kg and 0.65% and 4.04 kg respectively

But if its below this, you dont need to worry about reducing carbohydrates further

A dual GLP-1/GIP receptor agonist that typically produces greater weight loss than semaglutide, particularly for patients at higher BMIs or with significant insulin resistance

GIP receptor activation adds a complementary layer

This will help to control the off-label use of the drug, which is a significant cost driver