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Chronic low-grade inflammation, characterized by elevated levels of cytokines such as TNF- and IL-6, is frequently observed in patients with mood disorders and metabolic dysregulation [26,82,83]

Leading up to the Metsera acquisition, Pfizer management was pretty open about its interest in doing a deal to re-enter this space with differentiated long-acting and oral GLP-1 candidates

Zepbound dosing typically leads to sustainable weight loss without dramatic swings, along with metabolic benefits like enhanced blood sugar and cholesterol profiles

GLP-1 analogs effect on CNS: Satiety and weight loss The final beneficial effect of GLP-1, which is becoming quite a fad in doctors weight loss clinics, is its effect on satiety

Data availability The datasets analyzed during the current study are available from the corresponding author on reasonable request

New England Journal of Medicine, 387 (3), 205216