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In much of the modern world, in which the population is now exposed to widely available and vastly excessive calories as well as to increasingly sedentary lifestyles 56,57,58,59 , these ancient survival-ensuring mechanisms are not merely irrelevant, but actually counter-productive and contribute to the obesity epidemic

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Opioid use disorder manifests differently across individuals, influenced by genetic polymorphisms, early-life adversity, psychiatric comorbidities, and social determinants