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RF-409 is not expected to be universally effective across all classes of IR mutations but is well suited to variants that retain receptor expression and intrinsic kinase activity while being defective in insulin binding or ligand-induced activation, as illustrated by the IR D707A mutation

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Additionally, the majority of studies did not report adverse events stratified by age within adults, thus preventing subgroup analyses comparing adult and elderly subjects

Based on the predefined relevance criteria, none of the abstracts met the inclusion criteria
