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Doctors often suggest a combination of treatment plans

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contraindication during pregnancy and breastfeeding

Fetal abnormalities and variations in kidneys and blood vessels, irregular ossification of the skull, and a more complete state of ossification occurred at all doses

Prolonged inhibition of DPP may prevent the formation of GLP-1 (9-36) amide, and might ultimately augment oxidative stress in the heart, vasculature, and liver, and promote hepatic glucose production, which would be undesirable in the treatment of obesity-related diabetes

Ethics declarations Ethics approval and consent to participate As this study is a systematic review and meta-analysis of previously published data, ethical approval was not required by the authors institutional review board