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Obesity as well as type 2 diabetes are chronic conditions, so typically once a medication is started, its not stopped unless its replaced with something else

5 Glucose metabolism and insulin sensitivity Several mechanisms related to adrenergic stimulation may influence insulin sensitivity and glucose metabolism

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If you plan to drink occasionally, the safest approach is to wait until you've been stable on a dose for at least 2-3 weeks and your GI side effects have settled

study (16), it seems likely that this dichotomy extends to the brain