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Only dulaglutide treatment did not decrease TDI, however this was a small study (n=18) (52)

The Transition of Acute Postoperative Pain to Chronic Pain: An Integrative Overview of Research on Mechanisms

Preclinical studies have shown that large doses of GLP-1RAs can reduce lipid deposition and plaque volume on the aortic surface of hyperglycemic mice via an AMPK-independent action in streptozotocin (STZ)-induced hyperglycemic and hyperlipidemic mice or type 1 diabetic rats [55]

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In some cases, people experience mild injection site reactions, burping, hair shedding, or dizziness