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For example, clinical trials of semaglutide and tirzepatide report dyspepsia occurring in approximately 3-9% of patients, with GERD and belching/eructation also noted in some product labels

14 If a patient can achieve the same benefit by taking the branded GLP-1 and a separate vitamin supplement, then your combination product is a copy

Wong M et al

Diabetes Spectr 2017;30:202210 [DOI] [PMC free article] [PubMed] [Google Scholar] 64.Pratley R, Amod A, Hoff ST, et al

Choosing to invest in a weight loss drug ETF such as the Roundhill GLP-1 & Weight Loss ETF instead provides managed exposure to some of the most significant players in the field, as well as promising smaller companies leading research and innovation

But insurance companies want to keep costs down themselves, so many won't cover them for weight loss, or require patients to jump through frustrating hoops to get approval for coverage