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Tirzepatide achieved previously unheard-of results for a single agent in the SURPASS clinical trial program, lowering body weight by 5.411.7 kg and HbA1c by 1.24-2.58 percentage points

Low-risk combinations include tirzepatide with metformin, SGLT2 inhibitors (empagliflozin, dapagliflozin, canagliflozin), or thiazolidinediones (pioglitazone)

In other studies , people taking semaglutide reported feeling less hungry compared with those on placebo after 20 weeks of use and found that the effects continued to improve for up to two years

Unlike semaglutide which only targets GLP-1 receptors, tirzepatides additional GIP receptor activity is thought to enhance insulin secretion, improve insulin sensitivity, and produce greater reductions in appetite and body weight

[1] [4] For example, if your scheduled day is Saturday but you inject on Thursday, you must wait until at least Saturday (2 days later) for your next dose, then continue with weekly injections from your new day