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Description
They also reduce hepatic glucose output by decreasing hepatic FFA uptake and the expression of key gluconeogenesis enzymes such as PEPCK and G6Pase, while promoting hepatic sensitivity to insulin, transforming the liver from an "energy output organ" to an "energy storage organ"
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Tirzepatide is a dual GIP/GLP-1 receptor agonist used for type 2 diabetes (Mounjaro) and weight management (Zepbound), administered weekly by subcutaneous injection

Regulatory hurdles also pose a challenge, as companies must comply with strict FDA regulations regarding health claims associated with their products
The best way to keep patients safe is education and communication
Under certain conditions, cells can express PCSK1 and produce active GLP-1, but the mechanisms regulating cell PCSK1 expression are poorly defined
