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During this process, epithelial cells gradually lose their cobblestone epithelial appearance in monolayer cultures, along with cell-cell contact and adhesion capacity, and convert into a spindle-shaped mesenchymal phenotype that is more motile [80, 81]

That said, there is not much data on the long-term use of tirzepatide, so we dont fully understand what risks, if any, are associated with using this medication for long periods

10.1097/mog.0000000000001057 [DOI] [PubMed] [Google Scholar] Smits M

This delayed gastric transit can lead to gastric distension, increased pressure, and subsequent belching or eructation
m , Glucose-stimulated insulin secretion
