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Description
The ominous octet, which includes 8 key pathophysiologic defects found to be present in T2D, is illustrated in Figure 1
In particular, GLP-1R agonists, which have been approved by the FDA for the treatment of T2DM, are recently emerging as promising therapeutic agents in PD, increasing the expectations for identifying new PD drugs that could possibly be neuroprotective or even halt or reverse disease progression
the first is when a rapid pharmacological effect is required, such as with anti-hyperglycemic drugs that affect immediate post-prandial glucose excursions [48, 54]
[10] Day JW, et al
Called liraglutide, the company began clinical testing of the drug for diabetes in 1997
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