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Competing interests The authors declare no competing interests

In a study comparing tirzepatide and semaglutide, tirzepatide reduced HbA1c by 2.01% to 2.30%, depending on the dose, while semaglutide reduced it by 1.86% in 40 weeks 13

3,4 These incretins are rapidly inactivated by DPP-4, an enzyme expressed throughout the vascular endothelial cells, venous capillary beds, gut, liver, lungs, and kidneys

2 However, GLP-1 receptors are expressed throughout the human body and are not limited to pancreatic and gastrointestinal cell types

J Clin Invest 2023;133:e167700.ArticlePubMedPMC 31

The sensation of a "smaller stomach" stems from altered gastric accommodation and heightened sensitivity to fullness cues