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Description
Glucagon-like peptide 1 excites hypocretin/orexin neurons by direct and indirect mechanisms: implications for viscera-mediated arousal

If your blood glucose falls below 4.0 mmol/L, treat immediately with 1520g of fast-acting carbohydrate (such as glucose tablets, fruit juice, or sugary sweets), then recheck after 15 minutes, following NHS guidance on treating hypoglycaemia

however, this analysis did not evaluate causality

Separately, GLP-1 RA pretreatment in Abeta142-treated hippocampal primary cell cultures significantly increased phosphorylated CaMKII alpha -positive cells indicating that GLP-1 RAs may have neuroprotective effects through glutamate receptor-mediated responses.Reference Wang, Wang, Jiang, Yuan, Yu and Li 46 Taken together, GLP-1 RAs may have protective effects against neuropathological changes by promoting neurogenesis and synaptic plasticity


In contrast, GIP stimulates glucagon secretion, with enhanced activity at lower glycaemic levels
