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They also act on the appetite centers in the brain, significantly reducing hunger and what is often called food noise. The dual-action drug tirzepatide works on both GLP-1 and GIP receptors, often leading to even greater efficacy

Adverse events in relation to GLP-1R agonists for the treatment of obesity are mainly gastrointestinal side effects, including nausea, diarrhoea, vomiting and constipation, which is consistent with observations in type 2 diabetes, and rates of discontinuation due to adverse events are generally higher with GLP-1R agonists treatment compared with placebo [26, 30,31,32,33,34,35,36,37,38,39]

Arch Oral Biol 60(5):776781

These symptoms generally appear during the first few weeks of treatment, particularly during dose escalation phases when the body is adjusting to the drug

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Common Side Effects of Ozempic According to the manufacturer, the most frequent side effects involve digestion: Nausea Diarrhea Constipation Abdominal pain Vomiting These are most likely to occur when starting or increasing the dose