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Explored for benefits in obesity-related metabolic disorders

Obesity: GIP is involved in lipid accumulation

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Common adverse effects include nausea, vomiting, diarrhoea, constipation, and abdominal pain , particularly during the dose escalation phase (starting at 0.25 mg and gradually increasing to 2.4 mg over several weeks)

More receptor coverage = synergistic effects Appetite suppression (via Y2R) layered onto glycemic control & energy expenditure Smart design: lipidation, sequence grafting, and biasing GLP-1R signaling toward cAMP while avoiding -arrestin desensitization These arent just incremental add-ons

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