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GI Tolerability Differences Some patients experience persistent nausea on semaglutide but find tirzepatide easier to tolerate at equivalent dose stages, or vice versa

Strategies that help include eating adequate protein even when appetite is suppressed, staying hydrated, maintaining light physical activity (which paradoxically fights fatigue better than rest), and ensuring sufficient sleep

Sometimes stepping outside or opening a window when nausea hits provides relief

When any appears, scale back cardio, prioritize a higher-protein snack at the next meal, and recheck hydration

The GIP receptor component does something equally valuable

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