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Excess weight accelerates cartilage breakdown through increased mechanical stress and contributes to a pro-inflammatory state that may further damage joint structures

Trial participants experienced different levels of % total body weight loss depending on the dose: Percentage of total body weight loss on retatrutide After 48 weeks , 83% of patients taking 12 mg lost at least 15% of their body weight , compared to just 2% of those who were on a placebo

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GLP-1 secretion in response to endocrine factors 6.5.1

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