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The regulator said Mounjaro might be more effective than Wegovy, if taken alongside diet and exercise support, according to the draft recommendation text

Seek medical attention if you experience fatigue accompanied by: Severe gastrointestinal symptoms : Persistent vomiting or diarrhea lasting more than 24 hours, which may lead to dehydration and electrolyte imbalances Signs of dehydration : Decreased urination, dark urine, dizziness, rapid heartbeat, or confusion Abdominal pain : Particularly severe or persistent pain, which could indicate pancreatitis (a rare but serious adverse effect) Right upper quadrant pain : Pain with or without fever, jaundice, or clay-colored stools, which could indicate gallbladder disease Mood changes : New or worsening depression, anxiety, or suicidal thoughts Unexplained weight loss : Rapid weight loss exceeding recommended rates or unintended loss of muscle mass Hypoglycemia symptoms : Shakiness, sweating, confusion, or rapid heartbeat, especially if taking Zepbound with insulin or sulfonylureas

The market for weight-loss and diabetes drugs is heading into its most disruptive phase yet

If you have health conditions, take medications, are pregnant or nursing, or are considering health changes, consult your physician before starting any new treatment

Meta-analysis of the association between body mass index and health-related quality of life among adults, assessed by the SF-36

Early-phase clinical trials suggest that GLP-1 RA treatment may be neutral [43, 50] or even harmful in HFrEF patients, with or without diabetes, resulting in an increased risk of HF-related outcomes [51, 52]