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They are more a sign of adaptation than an indicator of the speed of metabolic benefits.

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Meanwhile, post-hoc analysis by Lingway et al [1] suggest that GI adverse effects contribute minimally (less than 0.1 kg) to the superior weight loss effects of semaglutide vs other GLP-1RAs

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For instance, while many companies require a BMI of 30 or higher, or 27 or higher, with a weight-related medical condition, some are now requiring a BMI of 35 or above to qualify, said Eileen Pincay, national pharmacy practice leader at Segal, a benefits and human resources consulting firm