long term side effects of glp 1 drugs Common GLP-1 Weight-loss The GLP-1 Agonists and Obesity:

Weight loss peptides work best when muscle is preserved, and adequate protein is the primary defense against muscle catabolism during caloric reduction

GLP-1RAs aid in weight loss by regulating the gut-brain axis and interacting with leptin, while weight loss can alleviate the harmful effects of obesity on the body, particularly in knee OA, by reducing joint loading and inflammation

All currently approved GLP-1RAs are administered systemically

Dual and triple agonists Tirzepatide is the first dual GIP/GLP-1 receptor agonist

[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Best JH, Hoogwerf BJ, Herman WH, Pelletier EM, Smith DB, Wenten M, Hussein MA

Bleeding Risk The most common adverse reactions when combining GLP-1R agonists with traditional antithrombotic drugs such as aspirin, clopidogrel, or direct oral anticoagulants (DOACs) include gastrointestinal symptoms of nausea, vomiting, abdominal cramping, and increased bleeding risks