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Quick look at the key results According to clinical trial investigators, orforglipron: Led to significant weight reduction across all dosing groups Showed greater effects at the highest dose levels Helped lower blood sugar in people with diabetes Supported modest improvements in blood pressure Demonstrated mainly mild to moderate side effects The trial results suggest that the once-daily pill performs competitively with early GLP-1 injection studies

[DOI] [PubMed] [Google Scholar] Maya J, Pant D, Fu Y, James K, Batlle C, Hsu S, Soria-Contreras DC, Shook LL, Mow C, Hivert M-F et al

Kommu S et al

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Most studies were judged to have a low risk of bias, but a few studies however showed moderate risk of bias

Because most trials do not screen for binge-eating symptoms, the available evidence likely reflects populations with mixed characteristics, and specific data for BED remain limited