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The goal isn't to feel miserable

GLP-1 medications offer effective tools when combined with proper thyroid hormone replacement and lifestyle modifications

GLP-1 receptor agonists exert their therapeutic effects through several mechanisms : they stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, suppress glucagon release (which reduces hepatic glucose production), slow gastric emptying, and act on appetite centres in the hypothalamus to promote satiety and reduce food intake

Cusimano MC, Sajewycz K, Nelson M, et al

Thyroid Hormones and Metabolism The thyroid plays a crucial role in weight loss and metabolism

People who were overweight or obese lost significant weight while taking retatrutide, which enabled them to be more active and reduced knee pain by an average of 4.5 points or about 76% based on pain scores from whats known as the Western Ontario and McMaster Universities Osteoarthritis Index