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The loss of sirtuin 6 (SIRT6), which regulates proinflammatory mediators, in human umbilical vein endothelial cells is associated with upregulation of the expression of proinflammatory genes [71]

J Clin Investig 130(12):66396655

This may be further pronounced in patients with diabetes with compromised gastrointestinal function due to autonomic neuropathy

Moreover, it has been reported that in type 2 diabetic patients with adequate glycaemic control by metformin monotherapy, several markers of cardiovascular risk are improved by addition of liraglutide treatment, suggesting that metformin and liraglutide may have additive or even synergistic effects on vasculature 14

Sanofi US 2022.

Specifically, it is a GGG tri-agonist affecting GLP-1, GIP, and glucagon receptors, which are crucial in regulating appetite and blood sugar