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NICE guidance emphasises individualised glycaemic targets, particularly when multiple medications affecting glucose metabolism are used concurrently

The mean Cmax and AUC0-120 increased 61% and 35%, respectively in subjects with severe renal impairment (GFR 80 mL/min) (see DOSAGE AND ADMINISTRATION)

As part of a larger crackdown on direct-to-consumer prescription drug advertising, the FDA published over 55 warning letters on September 16 to online sellers of compounded versions of the popular GLP-1 medications for type-2 diabetes and weight loss
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