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Your emphasis on thorough ophthalmic history and patient education is crucial

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elevated opening pressure (250mm cerebrospinal fluid [CSF] in adults) on lumbar puncture with normal CSF composition

This single methodological wrinkle invisible if one thinks of orforglipron as just an oral GLP-1 drug reshapes how the entire preclinical evidence base for the compound must be read, and it is a direct downstream consequence of the Trp33 binding detail resolved by cryo-EM