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39,40,43 There may be several possible explanations for the failure of GLP-1 RAs in HFrEF studies

Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide

Collectively, the results discussed above could be interpreted to suggest that conditions likely to result in -cell stress, such as obesity, hyperglycaemia, and inflammation, activate compensatory responses in an attempt to improve -cell function and survival

Let's break down exactly what the data shows, where the side effect risks shift, and who should actually consider making the move

It is not an injection, not a peptide, and not a GLP-1 receptor agonist

Future studies may explore the potential of GLP-1RAs in tumor therapy