semaglutide anesthesia guidelines Are Serious Risks of and Other GLP-1 Agonists Under-Recognized? Case Reports of Retained Solid Gastric Contents in Patients Undergoing Anesthesia When to Stop Semaglutide Before
Description
GLP-1 receptor agonists are intended for adults with obesity (BMI 30) or those who are overweight (BMI 27) with associated metabolic conditions such as hypertension, dyslipidaemia, or type 2 diabetes

GLP1R encodes the GLP-1 receptor involved in incretin signaling

A compounded alternative, dose restructuring, or dual-pathway therapy can reset this adaptation
But for significant muscle building, you still need progressive overload training and adequate protein (1.5-2g per kg bodyweight)

But for patients with restrictive eating disorders or a history of restriction, the dramatic appetite reduction could potentially trigger or worsen restrictive patterns
J Am Coll Cardiol 2024;84:1646-62.PubMed 98
