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In addition, according to observational and experimental data, DPP4 inhibitors [10, 11], sulfonylureas [11, 52], and insulin [53], are unlikely to slow cognitive decline beyond the benefits of glycemic control in diabetes without dementia

Half-Life Extension Strategies Apart from DPP-4 enzymolysis, another GLP-1/GIP degradation pathway, renal metabolism, can be overcome by augmenting the drug volume to prolong the half-life

American journal of physiology Endocrinology and metabolism
[8] [1] The Summary of Product Characteristics (SmPC) for all GLP-1 receptor agonists contains warnings about pancreatitis risk

f , Plasma glucagon levels during compound tolerance test

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