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3 The contribution of GLP-1 to bariatric surgery Post-prandial GLP-1 concentrations are increased following Roux-en-Y gastric bypass, an observation that has fuelled interest in investigating the role of GLP-1 in mediating weight loss and remission of metabolic derangements following surgery [32-34] All forms of bariatric surgery lead to weight loss to a greater or lesser extent

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Retatrutide targets three, GLP-1, GIP, and glucagon
