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Wondering if anyone else has any side effects after taking methotrexate, one myRAteam member wrote

For example, GLP-1R/GIPR dual agonists have demonstrated superior glucose-lowering and weight-loss effects in the treatment of diabetes and obesity

Obese mice given daily injections for two weeks lost an average of 3 grams almost entirely fat while untreated mice gained about 3 grams over the same period of time

But here is where things get complicated

Included outcomes were weight change from baseline (CFB, %) at 52 weeks and proportion of participants losing 5% baseline fasting body weight at 12 weeks (at full therapeutic dose)

[DOI] [PMC free article] [PubMed] [Google Scholar] 164.Ding J et al