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doi: 10.1111/obr.13841

Since mazdutide activates glucagon receptors as part of its core mechanism, liver fat reduction is a built-in benefit of the compound

J Clin Invest 2023;133:e167700.ArticlePubMedPMC 31

This guide breaks down everything researchers and patients need to know about retatrutide and Mounjaro (tirzepatide) , from molecular mechanisms and clinical trial data to real-world availability and practical considerations

The SELECT trial showed significant reduction in heart attacks, strokes, and cardiovascular death

However, some patients report better tolerability at equivalent weight loss levels, possibly due to the balancing effects of GIP