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Collectively, resistance to PD-1/PD-L1 blockade in NSCLC arises from multifactorial and interrelated processes involving both tumor-intrinsic and microenvironmental components

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Food and Drug Administration Adverse Event Reporting System (FAERS) database, spanning from 2004 to 2021, to investigate the association between glucagon-like peptide-1 receptor agonists (GLP-1RAs) and tumor-related adverse events

[Accessed on 11 June 2026] Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2) (2025)

Type 2 diabetes treatment requires in-person lab monitoring and frequent healthcare visits that go beyond telehealth capabilities