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The increased risk of amputation seen in the large, long-term Canagliflozin Cardiovascular Assessment Study (CANVAS) trial for canagliflozin, and select observational studies, merits further research but overall, there is currently no consistent evidence of SGLT2i exposure and increased risk of amputation

Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis

Reference O'Donnell, C., Ryan, O., Hogan, A

Reports suggest mood enhancement often occurs before substantial weight loss, within the first four to eight weeks of treatment

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