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In a Phase 2a substudy published in Nature Medicine, retatrutide at the 12mg dose reduced liver fat by an average of 82.4% from baseline at 24 weeks

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Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion

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But as researchers at Yale have pointed out, patients pursuing unvalidated microdosing protocols are essentially serving as their own test subjects on both efficacy and safety