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Availability of these commercialized incretin-based therapies in injectable and oral drug formats enables AstraZeneca to strongly compete in the market

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The gap between them is not 2x or 3x

369,370 Genetic disruption of GLP-1R signaling leads to cortical osteopenia and heightened bone fragility, primarily caused by increased bone resorption by osteoclasts

Our findings are relevant to a previous network meta-analysis that evaluated multiple types of glucose lowering drugs in patients with type 2 diabetes with HbA 1c as the endpoint and concluded that GLP-1RAs were the most effective in lowering HbA 1c concentrations