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For the quantification of each PDIA6 domain in the supernatant, all supernatants were separated by non-reducing SDSPAGE

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Using the BODIPY C11 assay, we observed that hypoxia increased lipid peroxidation in cultured proliferating and differentiating chondrocytes of both genotypes, but the most pronounced increase was observed in G6PDH-null differentiating hypoxic chondrocytes, which display the highest ROS levels (Extended Data Figs

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