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The half-life drives the spacing: Retatrutide's approximately 6-day half-life means a roughly 3.5-day gap leaves about two-thirds of the prior half-dose still circulating, smoothing the curve

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PLoS ONE 13(3):e0193473 Strazzullo P, DElia L, Kandala N-B, Cappuccio FP (2009) Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies

Think of it like warming a brandy glass, a slow rotation that moves the liquid without violence