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Clinical trial data and real-world evidence indicate that many patients regain a substantial portion of lost weight after discontinuation

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The same source noted that glucagon/GLP1 dual agonists, including mazdutide and survodutide, represent a way to target both weight and cardiometabolic health, given that glucagon receptors are mainly expressed in the liver

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The anti-apoptotic effect of GLP-1R agonism has been demonstrated in vivo in mice [543,550,551] and rats [552,553] as well as in several rodent [550,551] and human [554,555] cell lines, purified rat -cells [543], and humans [556]