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Whilst there is no direct drug-drug interaction between semaglutide and most thyroid medications, several indirect effects warrant attention

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Based on this evaluation, they recommend a suitable FDA-approved medication

Tsuchida and Friedman 2017)

Effects of intraduodenal glutamine on incretin hormone and insulin release, the glycemic response to an intraduodenal glucose infusion, and antropyloroduodenal motility in health and type 2 diabetes

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