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Specifically, GLP-1RAs activate the GLP-1R signaling pathway by crossing the BBB and in various extrahypothalamic regions, such as the cortex, thalamus, hypothalamus, brainstem, and hippocampus [45, 56]
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Preclinical studies have clearly demonstrated that GLP-1RAs effectively reduce hepatic macrophage infiltration and suppress expression of TNF- , IL-6, and other pro-inflammatory mediators in animal models of MASLD (21, 22)
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Safety and tolerability were assessed at all time points and during follow-up
Plan smaller meals: Your appetite will decrease, and your stomach will empty more slowly
