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In this paper, the authors describe the energy state-dependent regulation of the PVNGLP-1R to DVC circuit, resulting in altered food intake and metabolic health, mediated by GLP-1 receptor signalling.
The Glucagon-like peptide (GLP-1) receptor agonist semaglutide could help PLWH lose weight gained after starting ARTbut it may also exacerbate muscle loss or lipoatrophy.
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