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Endocrinologist Daniel Drucker at the University of Toronto heard about this discovery, because he was already interested in GLP-1, but did not understand why the gila monster would have something like that in its saliva

GLP-1(936) inhibited glucagon secretion by 55% at 1 mmol/l glucose and potentiated the glucagonostatic effect at 10 mmol/l glucose (50% compared with 10 mmol/l glucose alone)

SGLT2-i reduces both systolic blood pressure (SBP) and diastolic blood pressure (DBP) across multiple trials and meta-analyses with reductions up to 8.6/4.3 mmHg, depending on the agent, dose and population studied

Its taken once a week and was approved by the FDA in 2017 to treat type 2 diabetes

Instead, neuronal GLP-1Rs located outside the BBB primarily serve as peripheral targets for gut-derived or pharmacologically administered GLP-1 (Varin et al., 2019