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For tirzepatide, the approach is similar
When compared to single agonists, unimolecular dual incretin was more effective in correcting adiposity-induced insulin resistance in animal models of obesity and diabetes
doi: 10.1111/dom.14005 71 RiddleMCAronsonRHomePMarreMNiemoellerEMiossecPet al
In clinical trials for type 2 diabetes, Mounjaro produced weight loss of 9.5% to 12.5%
These same types of modifications (fatty acid chains, albumin binding) that work for pure GLP-1 agonists also extend tirzepatides duration
Deng, Y., et al
