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Description
Indeed, GIPR agonism can blunt the nauseating effects of GLP-1R agonists in humans (52)

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Competitive Arena Map 5

This translated into a significantly higher likelihood of achieving the conventional glycemic target of HbA1c 30, those randomized to tirzepatide experienced 36 adjudicated cardiovascular deaths or heart failure worsening events versus 56 in the placebo group, representing a 38% reduction primarily driven by fewer heart failure exacerbations

References Gao, J

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